ISSN 2673-494X
Two-page Reports on Science

Cuban Sci. 2020, 1(2): 7–8

Published on 29 Dec 2020 PDF (261K)
Inducible Nitric Oxide Synthase activity in human lung after cardiopulmonary bypass
Miriam Palacios-Callender
  • King's College London, London WC2B 4BG, United Kingdom
“The identification of the enzyme iNOS in human lungs after cardiopulmonary bypass was the result of the experimental and clinical cooperation of two teams aiming to identify new pathways in the pathophysiology of postoperative cardiac surgery.”


  1. Delgado, R., Rojas, A., Glaria, L.A., Torres, M.,Duarte, F., Shill, R., Nafeh, M., Santin, E., Gonzalez, N. and Palacios, M., Ca+2-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass, Thorax 50 (1995) 403-404
  2. Butler, J., Rocker, G.M. and Westaby, S., Inflammatory response to cardiopulmonary bypass, Ann. Throrac. Surg. 55 (1993) 552-559
  3. Rees, D.D., Role of nitric oxide in the vascular dysfunction of septic shock, Biochemical Transactions 234 (1995) 1025-1029
  4. Knowles, R.G. Palacios, M., Palmer, R.M.J. and Moncada, S., Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanism for stimulation of the soluble granulate cyclase, Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 5159-5162
  5. Salter, M., Knowles, R.G. and Moncada, S., Widespread tissue distribution, species distribution and changes in activity of Ca2+-dependent and Ca2+-independent nitric oxide syntheses, FEBS Letters 2911 (1991) 145-149
  6. Ratliff, N.B., Young, G.W., Hackel, D.B., Mikat,E. and Wilson, J.W., Pulmonary injury secondary to extracorporeal circulation, J. Thorac. Cardiovasc. Surg. 65 (1973) 425-432
  7. Salvemini, D., De Nuci, G., Grygleski, R.J. andVane, J.R., Human neutrophils and mononuclear cells inhibits platelet aggregation by realising a nitric oxide like factor, Proc. Natl. Acad. Sci. U.S.A. 89 (1989) 6328-46332
  8. Sair, M and Evans, T.W., NO news is good news, Thorax 50 (1995) 323-4324
  9. Braude, S, Nolan, K.B., Flemming J.S., Krausz,T., Taylor, K.M. and Royston, D., Increased pulmonary transvascular protein flux after canine cardiopulmonary bypass. Association with lung neutrophils sequestration and tissue peroxidation, Am. Rev. Respir. Dis. 134 (1986) 867-892
  10. Bazan-Milan, M., Delgado Bereijo, L. and Gonzalez-Jimenez, N., Morbimortality in Heart and Lung Transplantation in Cuba: 20 years follow-up, Transplantation Proceedings 418 (2009) 3507-3509