Cuban Sci. 2020, 1(1): 19–20
Published on 22 May 2020 PDF (942K)Novel HIV matrix shell structure and potential functions
Marcelo Marcet-Palacios
- Northern Alberta Institute of Technology, Edmonton, Canada
- University of Alberta, Edmonton, Canada
“The structure of the HIV matrix shell has not been fully elucidated. In this article, I highlight contributions that led to a model composed of adjacent hexagons forming a sphere and mentioned studies that were subsequently impacted. A cross-disciplinary group of students in my lab tested this hypothesis and conclusively demonstrated that this model was incorrect. I provide a summary of our results with emphasis placed on contributions made by students.”
References
- Sun, W., Reyes-Serratos, E., Barilla, D., Santos, J. R. L., Bujold, M., Graves, S., and Marcet-Palacios, M., PLoS One, 14,11 (2019) e0224965.
- Alfadhli, A., Barklis, R. L., and Barklis, E. (2009). Virology, 387,2 (2009) 466-472.
- Briggs, J. A., Riches, J. D., Glass, B., Bartonova, V., Zanetti, G., and Krausslich, H. G., Proc Natl Acad Sci U S A, 106, 27(2009) 11090-11095.
- Tedbury, P. R., Ablan, S. D. and Freed, E. O., PLoS Pathog, 9, 11 (2013) e1003739.
- Bharat, T. A., Castillo Menendez, L. R., Hagen, W. J., Lux, V., Igonet, S., Schorb, M., Schur, F.K., Krausslich, H.G. and Briggs, J. A., Proc Natl Acad Sci U S A, 111,22 (2014) 8233-8238.
- Carlson, L. A., Bai, Y., Keane, S. C., Doudna, J. A. and Hurley, J. H., Elife, 5 (2016).
- Tomasini, M. D., Johnson, D. S., Mincer, J. S. and Simon, S. M., PLoS One, 13,4 (2018) e0196133.
- Liu, Y. and Zou, X, Bull Math Biol, 81,5 (2019) 1506-1526.
- Hill, C. P., Worthylake, D., Bancroft, D. P., Christensen, A. M. and Sundquist, W. I., Proc Natl Acad Sci U S A, 93,7 (1996) 3099-3104.
- Saad, J. S., Loeliger, E., Luncsford, P., Liriano, M., Tai, J., Kim, A., Miller, J., Joshi, A., Freed, E.O. and Summers, M. F., J Mol Biol, 366,2 (2007) 574-585.
- Euler, L. (1758) Novi comm. acad. scientiarum imperialis petropolitanae, 4,109-160 (1758) 1752-1753.