ISSN 2673-494X
Two-page Reports on Science

Cuban Sci. 2020, 1(2): 5–6

Published on 3 Nov 2020 PDF (356K)
Anti-angiogenic effects of Mangiferin in metastatic melanoma. A fair tale of two worlds.
René Delgado-Hernández, Ivones Hernández-Balmaseda, Idania Rodeiro-Guerra, Julio Cesar Rodríguez Gonzalez, Olivier De Wever, Emilie Logie, Ken Declerck, Claudina Pérez-Novo, Wim Vanden Berghe
  • IFAL, Universidad de La Habana, Cuba
  • ICIMAR, CITMA, La Habana, Cuba
  • CIDEM, BioCubaFarma, La Habana, Cuba
  • ROECR, University Hospital Gent, Gent, Belgium
  • PPES, Biomedical Sciences, University of Antwerp, Antwerp, Belgium
“We described here how international collaboration can validate the preclinical research of a new use for a given molecule produced in Cuba while strengthening the scientific capacity of the country.”

References

  1. Nuñez-Selles A.J., Daglia, M.; Rastrelli, L. , The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptotic, and gene-regulatory effects, BioFactors, 42 5 (2016) 475-9
  2. Nuñez-Selles, A.J., Delgado-Hernández, R., Garrido-Garrido, G., García-Rivera, D., Guevara-García, M.; Pardo-Andreu, G.L. , The paradox of natural products as pharmaceuticals: Experimental evidences of a mango stem bark extract., Pharmacol Res, 55 5 (2007) 351-8
  3. Delgado-Hernández, R., Hernández-Balmaseda, I., Rodeiro-Guerra, I., Rodríguez-González, J.C., De Wever, O., Logie, E., Declerck, K., Pérez-Novo, C.; Vanden Berghe, W. , Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma, Melanoma Research, 30 (2020) 39-51
  4. García-Rivera, D., Delgado R., Bougarne, N., Haegeman G.; Vanden Berghe, W , Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mango bark extract in MDA-MB231 breast cancer cells, Cancer Letter, 305 (2011) 21-31